Descripción:
Objective – To evaluate the efficacy and safety of trifarotene plus oral doxycycline in the treatment of acne. Methods – This was a randomized, 2:1 ratio double-blind, 12 week study. The included population was patients who were 12 years or older with severe facial acne (≥20 inflammatory lesions, 30 to 120 non-inflammatory lesions, and ≤4 nodules). They were given once-daily trifarotene cream 50µg/g plus enteric-coated doxycycline 120mg (T+D) versus trifarotene vehicle and doxycycline placebo (V+P) and followed up. Positive outcomes of the treatment included changing of the number of lesions from baseline and global investigator-assessed (IGA) success (≥2-grade improvement with a score of 0/1). Safety was evaluated based on adverse events and local tolerability
